New insights into Epstein‑Barr virus‑associated tumors: Exosomes (Review).
Chen W, Xie Y, Wang T, Wang L.
Oncology reports. 2022; 47(1):

Abstract

EpsteinBarr virus (EBV) is endemic worldwide and is associated with a number of human tumors. EBVassociated tumors have unique mechanisms of tumorigenesis. EBV encodes multiple oncogenic molecules that can be loaded into exosomes released by EBV(+) tumor cells to mediate intercellular communication. Moreover, different EBV(+) tumor cells secrete exosomes that act on various target cells with various biological functions. In addition to oncogenicity, EBV(+) exosomes have potential immunosuppressive effects. Investigating EBV(+) exosomes could identify the role of EBV in tumorigenesis and progression. The present review summarized advances in studies focusing on exosomes and the functions of EBV(+) exosomes derived from different EBVassociated tumors. EBV(+) exosomes are expected to become a new biomarker for disease diagnosis and prognosis. Therefore, exosometargeted therapy displays potential.



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