Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum.
Li P, Zhou B, Ge M, Jing X, Yang L.
Talanta. 2022; 237(): 122913

Abstract

Sensitivity and credibility detecting histamine (HA) as an important neurotransmitter in biofluids is of importance in analytical science and physiology. Surface-enhanced Raman spectroscopy (SERS) is able to realize the high sensitivity with single molecules level, but providing the high sensitivity for HA with a small cross section remains a challenge. Here we develop the metal complex-based SERS nanoprobe nitrilotriacetic acid-Ni(2+) (NTA-Ni(2+)) combined with self-assemble Au NPs active substrates for sensitive detection of HA. The NTA-Ni(2+) can capture the HA molecules close to Au NPs substrates and then amplify the Raman signals of HA owing to the formation of a complex of NTA-Ni(2+)-HA. The self-assemble Au film through the evaporation-driven method can provide the high-density hot spots substrate with high stability and reproducibility. The NTA-Ni(2+) decorated Au NPs as nanoprobe responds to HA with 1 muM level of sensitivity. More importantly, the developed SERS nanoprobe composing of NTA-Ni(2+) and self-assemble Au NPs can be utilized to detect and monitor the HA spiked into serum, indicating the potential prospect in analysis of HA in complex specimen. CI - Copyright (c) 2021 Elsevier B.V. All rights reserved.



P A G E S

Home
Journals
Keywords

P A R T N E R S

ScopeMed
BiblioMed
eJManager

Privacy Policy | citeindex.org © 2021
ScopeMed Web Sites